Katherine Hart

Lecturer in Veterinary Nursing, Department of Animal Health, Behaviour and Welfare, Harper Adams University, Edgmond, Newport, TF10 8NB

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Figure 1. (a) Buccal swab sampling in a Shetland sheepdog for MDR1 gene mutation testing; (b) Kennel sign for high-risk dogs whose MDR1 genotype is unknown; (c) A hospitalised German shepherd with signage on its kennel confirming it has the MDR1 gene mutation.

Multidrug resistance 1 (MDR1) gene mutation in dogs

An overview of genotype possibilities is included in Table 1. In summary, these are homozygous normal (unaffected), heterozygous or homozygous mutations (affected). Offspring can inherit this gene if...