References

Bizikova P, Santoro D, Marsella R, Nuttall T, Eisenschenk MN, Pucheu-Haston CM Review: Clinical and histological manifestations of canine atopic dermatitis. Vet Dermatol. 2015a; 26:(2)79-e24 https://doi.org/10.1111/vde.121969

Bizikova P, Pucheu-Haston CM, Eisenschenk MNC, Marsella R, Nuttall T, Santoro D Review: role of genetics and the environment in the pathogenesis of canine atopic dermatitis. Vet Dermatol. 2015b; 26:(2)95-e26 https://doi.org/10.1111/vde.12198

Brandt EB, Sivaprasad U Th2 cytokines and atopic dermatitis. J Clin Cell Immunol. 2011; 2:(3) https://doi.org/10.4172/2155-9899.1000110

Chermprapai S, Broere F, Gooris G, Schlotter YM, Rutten VPMG, Bouwstra JA Altered lipid properties of the stratum corneum in Canine Atopic Dermatitis. Biochim Biophys Acta Biomembr. 2018; 1860:(2)526-533 https://doi.org/10.1016/j.bbamem.2017.11.013

Combarros D, Cadiergues MC, Simon M Update on canine filaggrin: a review. Vet Q. 2020; 40:(1)162-168 https://doi.org/10.1080/01652176.2020.1758357

Danforth Animal Hospital. Canine allergies. 2021. https://www.danforthanimal.com/blog/97001-canine-allergies (accessed 9 July 2024)

DeBoer DJ, Hillier A The ACVD task force on canine atopic dermatitis (XV): fundamental concepts in clinical diagnosis. Vet Immunol Immunopathol. 2001; 81:(3-4)271-276 https://doi.org/10.1016/S0165-2427(01)00312-9

Favrot C Clinical signs and diagnosis of canine atopic dermatitis. Eur J Companion Anim Pract. 2009; 19:(3)219-222

Favrot C, Steffan J, Seewald W, Picco F A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis. Vet Dermatol. 2010; 21:(1)23-31 https://doi.org/10.1111/j.1365-3164.2009.00758.x

Garland M Introduction to canine skin and dermatology. Vet Nurs J. 2013; 28:(4)131-133 https://doi.org/10.1111/vnj.12025

Gaudiano F Atopic skin disease – diagnosis and treatment. Vet Nurs. 2013; 28:(5)154-158 https://doi.org/10.1111/vnj.12031

Gedon NKY, Mueller RS Atopic dermatitis in cats and dogs: a difficult disease for animals and owners. Clin Transl Allergy. 2018; 8:(1) https://doi.org/10.1186/s13601-018-0228-5

Griffin CE, DeBoer DJ The ACVD task force on canine atopic dermatitis (XIV): clinical manifestations of canine atopic dermatitis. Vet Immunol Immunopathol. 2001; 81:(3-4)255-269 https://doi.org/10.1016/S0165-2427(01)00346-4

Hensel P, Santoro D, Favrot C, Hill P, Griffin C Canine atopic dermatitis: detailed guidelines for diagnosis and allergen identification. BMC Vet Res. 2015; 11:(1) https://doi.org/10.1186/s12917-015-0515-5

Hill PB, DeBoer DJ The ACVD task force on canine atopic dermatitis (IV): environmental allergens. Vet Immunol Immunopathol. 2001; 81:(3-4)169-186 https://doi.org/10.1016/S0165-2427(01)00298-7

Hill PB, Lo A, Eden CA Survey of the prevalence, diagnosis and treatment of dermatological conditions in small animals in general practice. Vet Rec. 2006; 158:(16)533-539 https://doi.org/10.1136/vr.158.16.533

Hillier A, Griffin CE The ACVD task force on canine atopic dermatitis (X): is there a relationship between canine atopic dermatitis and cutaneous adverse food reactions?. Vet Immunol Immunopathol. 2001; 81:(3-4)227-231 https://doi.org/10.1016/S0165-2427(01)00302-6

What is new in the diagnosis and management of canine atopic dermatitis. 2015. https://todaysveterinarypractice.com/dermatology-details-new-diagnosis-management-canine-atopic-dermatitis/ (accessed 9 July 2024)

Little PR, King VL, Davis KR, Cosgrove SB, Stegemann MR A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. Vet Dermatol. 2015; 26:(1)23-30 https://doi.org/10.1111/vde.12186

Lloyd D, Patel A Structure and function of the skin. BSAVA Manual of Canine and Feline Dermatology. 2012; 1-11

Marsella R, De Benedetto A Atopic dermatitis in animals and people: an update and comparative review. Vet Sci. 2017; 4:(3) https://doi.org/10.3390/vetsci4030037

Marsella R, Sousa CA, Gonzales AJ, Fadok VA Current understanding of the pathophysiologic mechanisms of canine atopic dermatitis. J Am Vet Med Assoc. 2012; 241:(2)194-207 https://doi.org/10.2460/javma.241.2.194

Moyaert H, Van Brussel L, Borowski S A blinded, randomized clinical trial evaluating the efficacy and safety of lokivetmab compared to ciclosporin in client-owned dogs with atopic dermatitis. Vet Dermatol. 2017; 28:(6)593-e145 https://doi.org/10.1111/vde.12478

Olivry T Could we use the erythema grading of the CADESI 4 as a simple instrument for future short-duration clinical trials of dogs with atopic dermatitis?. Vet Dermatol. 2019; 30:(1)80-81 https://doi.org/10.1111/vde.12709

Olivry T, DeBoer DJ, Griffin CE The ACVD task force on canine atopic dermatitis: forewords and lexicon. Vet Immunol Immunopathol. 2001; 81:(3-4)143-146 https://doi.org/10.1016/S0165-2427(01)00343-9

Olivry T, Marsella R, Iwasaki T, Mueller R Validation of CADESI-03, a severity scale for clinical trials enrolling dogs with atopic dermatitis. Vet Dermatol. 2007; 18:(2)78-86 https://doi.org/10.1111/j.1365-3164.2007.00569.x

Olivry T, Saridomichelakis M, Nuttall T, Bensignor E, Griffin CE, Hill PB Validation of the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, a simplified severity scale for assessing skin lesions of atopic dermatitis in dogs. Vet Dermatol. 2014; 25:(2)77-85 https://doi.org/10.1111/vde.12107

Paterson S Canine atopic dermatitis — the veterinary ‘eczema’ nurse. The Veterinary Nurse. 2019; 10:(6)296-303 https://doi.org/10.12968/vetn.2019.10.6.296

Plant JD, Gortel K, Kovalik M, Polissar NL, Neradilek MB Development and validation of the Canine Atopic Dermatitis Lesion Index, a scale for the rapid scoring of lesion severity in canine atopic dermatitis. Vet Dermatol. 2012; 23:(6)515-e103 https://doi.org/10.1111/j.1365-3164.2012.01113.x

Prelaud P, Laprais A What can we learn from canine atopic dermatitis history?. Curr Dermatol Rep. 2020; 9:(1)52-57 https://doi.org/10.1007/s13671-020-00292-4

Pucheu-Haston CM, Bizikova P, Eisenschenk MNC, Santoro D, Nuttall T, Marsella R Review: the role of antibodies, autoantigens and food allergens in canine atopic dermatitis. Vet Dermatol. 2015; 26:(2)115-e30 https://doi.org/10.1111/vde.12201

Safari Veterinary Care Centers. Dermatology: structure & function of skin in dogs. https://www.safarivet.com/care-topics/dogs-and-cats/dermatology (accessed 9 July 2024)

Santoro D, Marsella R, Pucheu-Haston CM, Eisenschenk MNC, Nuttall T, Bizikova P Review: Pathogenesis of canine atopic dermatitis: skin barrier and host–micro-organism interaction. Vet Dermatol. 2015; 26:(2)84-e25 https://doi.org/10.1111/vde.12197

Saridomichelakis MN, Olivry T An update on the treatment of canine atopic dermatitis. Vet J. 2016; 207:29-37 https://doi.org/10.1016/j.tvjl.2015.09.016

van der Velden VHJ Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma. Mediators Inflamm. 1998; 7:(4)229-237 https://doi.org/10.1080/09629359890910

Understanding canine atopic dermatitis

02 July 2024
13 mins read
Volume 15 · Issue 6

Abstract

It is important for veterinary nurses to understand that canine apotic dermatitis is a disease that can resemble many other pruritic skin diseases and to be aware of the many skin issues that can occur when carrying out consultations, conducting telephone triages and booking consultations, as first opinion practices are inundated with itchy dog phone calls. Research has found that pruritic skin disease accounts for just under half of dermatological problems in first opinion practice. Canine apotic dermatitis can very easily be misdiagnosed and mistreated for other skin issues or diseases.

Veterinary nurses are often asked about skin conditions and it is important to understand that canine atopic dermatitis can resemble many other pruritic skin diseases and to be aware of the many skin issues that can occur when carrying out consultations, conducting telephone triages and booking consultations, as first opinion practices are inundated with itchy dog phone calls. Hill et al (2006) state that pruritic skin disease accounts for just under half of dermatological problems in first opinion practice. Canine atopic dermatitis can very easily be misdiagnosed for other skin issues or diseases which resemble canine atopic dermatitis.

Canine atopic dermatitis is a common and complex allergic skin disease that affects canines all over the world. It is defined by the American College of Veterinary Dermatology as ‘a genetically predisposed inflammatory and pruritic allergic skin disease with characteristic clinical features associated with IgE antibodies most commonly directed against environmental allergens’ (Olivry et al, 2001; Bizikova et al, 2015a; Santoro et al, 2015). This is the ‘inside-outside’ theory. The ‘inside-outside’ theory proposes that a loss of skin barrier function allows allergens and microbes to easily penetrate through the epidermis, which increases allergen exposure to epidermal immune cells (Santoro et al, 2015).

Register now to continue reading

Thank you for visiting The Veterinary Nurse and reading some of our peer-reviewed content for veterinary professionals. To continue reading this article, please register today.