References

Anadón A, Martínez-Larrañaga MR, Martínez MA. Use and abuse of pyrethrins and synthetic pyrethroids in veterinary medicine. Vet J. 2009; 182:(1)7-20 https://doi.org/10.1016/j.tvjl.2008.04.008

Arp LH, Richard JL. Intoxication of dogs with the mycotoxin penitrem A. J Am Vet Med Assoc. 1979; 175:565-566

Ashton CH. Pharmacology and effects of cannabis: a brief review. Br J Psychiatry. 2001; 178:101-106

Bates N. Chocolate toxicity. Companion Animal. 2015; 20:(10)579-581 https://doi.org/10.12968/coan.2015.20.10.579

Bates N. Xylitol toxicosis in dogs. UK-Vet Companion Animal. 2019; 24:(4)182-187 https://doi.org/10.12968/coan.2019.24.4.182

Bates NS, Sutton NM, Campbell A. Suspected metaldehyde slug bait poisoning in dogs: a retrospective analysis of cases reported to the Veterinary Poisons Information Service. Vet Rec. 2012; 171:(13)

Bates N, Chatterton J, Robbins C Lipid infusion in the management of poisoning: a report of 6 canine cases. Vet Rec. 2013; 172:(13) https://doi.org/10.1136/vr.101036

Becker MD, Young BC. Treatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011-2014). Vet Med (Auckl). 2017; 8:77-85 https://doi.org/10.2147/VMRR.S129576

Bishop CHG. Blindness associated with metaldehyde poisoning. Vet Rec. 1975; 96:(19)

Booze TF, Oehme FW. Metaldehyde toxicity: a review. Vet Hum Toxicol. 1985; 27:(1)11-19

Boysen SR, Rozanski EA, Chan DL, Grobe TL, Fallon MJ, Rush JE. Tremorgenic mycotoxicosis in four dogs from a single household. J Am Vet Med Assoc. 2002; 221:(10)1441-4

Bradford HF, Norris PJ, Smith CC. Changes in transmitter release patterns in vitro induced by tremorgenic mycotoxins. J Environ Pathol Toxicol Oncol. 1990; 10:(1-2)17-30

Brückner M, Schwedes CS. Successful treatment of permethrin toxicosis in two cats with an intravenous lipid administration. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2012; 40:129-134

Buchta R Deliberate intoxication of young children and pets with drugs: a survey of an adolescent population in a private practice. Am J Dis Child. 1988; 142:701-702

Burrows GE, Tyrl RJ. Toxic plants of North America.Ames (IA): Iowa State University Press; 2001

Catovic S, Filipovic N, Stern P. The effect of penitrem A upon the level of glycine in the CNS. Bull Scientifique. 1975; 20:284-285

Clarke DL, Lee JA, Murphy LA, Reineke EL. Use of intravenous lipid emulsion to treat ivermectin toxicosis in a Border Collie. J Am Vet Med Assoc. 2011; 239:(10)1328-1333 https://doi.org/10.2460/javma.239.10.1328

DeGroot WD. Intravenous lipid emulsion for treating permethrin toxicosis in a cat. Can Vet J. 2014; 55:(1)1253-4

Dolder LK. Metaldehyde toxicosis. Vet Med. 2003; 98:(30)213-215

Donaldson CW. Marijuana exposure in animals. Vet Med. 2002; 97:(6)437-439

Dumonceaux GA, Beasley VR Emergency treatments for police dogs used for illicit drug detection. J Am Vet Med Assoc. 1990; 197:(2)185-187

Edwards G. Ivermectin: does P-glycoprotein play a role in neurotoxicity?. Filaria J. 2003; 2:(S1)

Epstein SE, Hollingsworth SR. Ivermectin-induced blindness treated with intravenous lipid therapy in a dog. J Vet Emerg Crit Care (San Antonio). 2013; 23:(1)58-62 https://doi.org/10.1111/vec.12016

Eriksen GS, Hultin Jäderlund K, Moldes-Anaya A Poisoning of dogs with tremorgenic Penicillium toxins. Med Mycol. 2010; 8:(1)188-196

Fabritius M, Staub C, Mangin P, Giroud C. Distribution of free and conjugated cannabinoids in human bile samples. Forensic Sci Int. 2012; 223:(1-3)114-118 https://doi.org/10.1016/j.forsciint.2012.08.013

Fitzgerald KT, Bronstein AC, Newquist KL. Marijuana poisoning. Top Companion Anim Med. 2013; 28:(1)8-12 https://doi.org/10.1053/j.tcam.2013.03.004

Garrett ER, Hunt CA. Pharmacokinetics of delta9-tetrahydrocannabinol in dogs. J Pharm Sci. 1977; 66:(3)395-407

Godbold JC, Hawkins BJ, Woodward MG. Acute oral marijuana poisoning in the dog. J Am Vet Med Assoc. 1979; 175:(10)1101-1102

Hansen SR. Pyrethrins and pyrethroids, 3rd edn. In: Peterson ME, Talcott PA (eds). ST Louis (MO): Elsevier Saunders; 2013

Haworth MD, Smart L. Use of intravenous lipid therapy in three cases of feline permethrin toxicosis. J Vet Emerg Crit Care (San Antonio). 2012; 22:(6)697-702 https://doi.org/10.1111/j.1476-4431.2012.00804.x

Heit JE, Tranquilli WJ, Parker AJ, Paul AJ, Sisson D. Clinical management of ivermectin overdose in a Collie dog. Compan Anim Pract. 1989; 19:(1)3-7

Hocking AD, Holds K, Tobin NF. Intoxication by tremorgenic mycotoxin (penitrem A) in a dog. Aust Vet J. 1988; 65:(3)82-85

Homeida AM, Cooke RG. Pharmacological aspects of metaldehyde poisoning in mice. J Vet Pharmacol Therap. 1982a; 5:77-81

Homeida AM, Cooke RG. Anti-convulsant activity of diazepam and clonidine on metaldehyde-induced seizures in mice: effects on brain gamma-amino butyric acid concentrations and monoamine oxidase activity. J Vet Pharmacol Therap. 1982b; 5:187-190

Hopper K, Aldrich J, Haskins SC. Ivermectin toxicity in 17 collies. J Vet Intern Med. 2002; 16:(1)89-94

James OD. Metaldehyde poisoning. Vet Rec. 1955; 67

Janczyk P, Donaldson CW, Gwaltney S. Two hundred and thirteen cases of marijuana toxicoses in dogs. Vet Hum Toxicol. 2004; 46:(1)19-21

Jones DL. A case of canine cannabis ingestion. NZ Vet J. 1978; 26:135-136

Jourdan G, Boyer G, Raymond-Letron I, Bouhsira E, Bedel B, Verwaerde P. Intravenous lipid emulsion therapy in 20 cats accidentally overdosed with ivermectin. J Vet Emerg Crit Care (San Antonio). 2015; 25:(5)667-671 https://doi.org/10.1111/vec.12371

Kenny PJ, Vernau KM, Puschner B, Maggs DJ. Retinopathy associated with ivermectin toxicosis in two dogs. J Am Vet Med Assoc. 2008; 233:(2)279-284

Kidwell JH, Buckley GJ, Allen AE, Bandt C. Use of IV lipid emulsion for treatment of ivermectin toxicosis in a cat. J Am Anim Hosp Assoc. 2014; 50:(1)59-61 https://doi.org/10.5326/JAAHA-MS-5951

Kisseberth WC, Trammel HL. Illicit and abused drugs. Vet Clin North Am Small Anim Pract. 1990; 20:(2)405-418

Klainbart S, Merbl Y, Kelmer E, Cuneah O, Edery N, Shimshoni JA. Tremor-salivation syndrome in canine following pyrethroid/permethrin intoxication. Pharmaceutica Analytica Acta. 2014; 5:(9) https://doi.org/10.4172/2153-2435.1000320

Kormpou F, O'Sullivan A, Troth L, Adamantos S. Use of intravenous lipid emulsion in dogs with suspected tremorgenic mycotoxicosis: 53 cases. Vet Evidence. 2018; 3:(2)1-8 https://doi.org/10.18849/ve.v3i2.166

Kruidenier M, Veling W, de Vries I, Meulenbelt J. Are pets more vulnerable to cannabis intoxication than humans? [abstract]. Clin Toxicol (Phila). 2008; 46:(5)

Kuo K, Odunayo A. Adjunctive therapy with intravenous lipid emulsion and methocarbamol for permethrin toxicity in 2 cats. J Vet Emerg Crit Care (San Antonio). 2013; 23:(4)436-41 https://doi.org/10.1111/vec.12070

Laws I, Mantle PG. Elimination of roquefortine in the rat. Mycotoxin Res. 1987; 3:(1)3-6

Laws I, Mantle PG, Smith BL. Excretion and transformation of [14C] penitrem mycotoxins in sheep bile. Res Vet Sci. 1987; 43:(2)199-202

Llera RM, Volmer PA. Toxicologic hazards for police dogs involved in drug detection. J Am Vet Med Assoc. 2006; 228:(7)1028-1032

Lowes NR, Smith RA, Beck BE. Roquefortine in the stomach contents of dogs suspected of strychnine poisoning in Alberta. Can Vet J. 1992; 33

Mauser EL, Puschner B, Reese S, Hartmann K, Doerfelt R. Evaluation of the in vitro efficacy of hemodialysis, hemoperfusion, and the combined approach on the removal of metaldehyde from canine plasma. J Vet Emerg Crit Care (San Antonio). 2016; 26:(4)516-23 https://doi.org/10.1111/vec.12487

McKnight K. Marijuana toxicosis. Vet Tech. 2003; 24:(4)264-265

Mealey KL. Canine ABCB1 and macrocyclic lactones: heartworm prevention and pharmacogenetics. Vet Parasitol. 2008; 158:(3)215-22 https://doi.org/10.1016/j.vetpar.2008.09.009

Mealey KL, Bentjen SA, Gay JM, Cantor GH. Ivermectin sensitivity in collies is associated with a deletion mutation of the MDR1 gene. Pharmacogenetics. 2001; 11:(8)727-733

Meola SD, Tearney CC, Haas SA, Hackett TB, Mazzaferro EM. Evaluation of trends in marijuana toxicosis in dogs living in a state with legalized medical marijuana: 125 dogs (2005-2010). J Vet Emerg Crit Care (San Antonio). 2012; 22:(6)690-6 https://doi.org/10.1111/j.1476-4431.2012.00818.x

Meyer EK. Toxicosis in cats erroneously treated with 45% to 65% permethrin products. J Am Vet Med Assoc. 1999; 215:198-203

Muentener CR, Spicher C, Page SW. Treating permethrin poisoning in cats. Vet Rec. 2013; 172:(24) https://doi.org/10.1136/vr.f3632

Munday JS, Thompson D, Finch SC Presumptive tremorgenic mycotoxicosis in a dog in New Zealand, after eating mouldy walnuts. N Z Vet J. 2008; 56:(3)145-8 https://doi.org/10.1080/00480169.2008.36823

Naude TW, O'Brien OM, Rundberget T, McGregor AD, Roux C, Flaoyen A. Tremorgenic neuromycotoxicosis in 2 dogs ascribed to the ingestion of penitrem A and possibly roquefortine in rice contaminated with Penicillium crustosum. J S Afr Vet Assoc. 2002; 73:(4)211-215

Norris PJ, Smith CCT, Belleroche JD, Bradford HF, Mantle PG, Thomas AJ, Penny RHC. Actions of tremorgenic fungal toxins on neurotransmitter release. J Neurochemistry. 1980; 34:33-44

Paul AJ, Tranquilli WJ, Seward RL, Todd KS, DiPietro JA. Clinical observations in Collies given ivermectin orally. Am J Vet Res. 1987; 48:(4)684-685

Peacock RE, Hosgood G, Swindells KL, Smart L. A randomized, controlled clinical trial of intravenous lipid emulsion as an adjunctive treatment for permethrin toxicosis in cats. J Vet Emerg Crit Care (San Antonio). 2015; 25:(5)597-605 https://doi.org/10.1111/vec.12322

Puls R, Ladyman E. Roquefortine toxicity in a dog. Can Vet J. 1988; 29

Puschner B. Mycotoxins. Vet Clin North Am Small Anim Pract. 2002; 32:(2)409-419

Puschner B. Penitrem A and roquefortine. In: Plumlee KH (ed). St Louis (MO): Mosby; 2004

Richard JL, Bacchetti P, Arp LH. Moldy walnut toxicosis in a dog, caused by the mycotoxin penitrem A. Mycopathologia. 1981; 76:55-58

Richardson JA. Permethrin spot-on toxicosis in cats. J Vet Emerg Crit Care. 1999; 10:103-106

Robertson ID, Dorling PR, Shaw SE. A prospective study of intoxications in dogs and cats in Western Australia. Aust Vet Pract. 1992; 22:78-85

Schwartz RH, Riddle M. Marijuana intoxication in pets. J Am Vet Med Assoc. 1985; 187:(3)

Snowden NJ, Helyar CV, Platt SR, Penderis J. Clinical presentation and management of moxidectin toxicity in two dogs. J Small Anim Pract. 2006; 47:(10)620-624

Sparks SE, Quistad GB, Cole LM, Casida JE. Metaldehyde molluscicide action in mice: Distribution, metabolism, and possible relation to GABAergic system. Pesticide Biochem Physiol. 1996; 55:226-236

Studdert VP. Incidence of poisoning in dogs and cats in Melbourne. Aust Vet J. 1985; 62:133-135

Sturgeon K, Campbell A. Dopey dogs – a review of cannabis exposure in canines [abstract]. Clin Toxicol (Phila). 2008; 46:(5)

Taylor N. Chocolate Glastonbury hash cookies. Control & Therapy Series. 2011; 263

Teichmann-Knorrn S, Doerfelt S, Doerfelt R. Retrospective evaluation of the use of hemodialysis in dogs with suspected metaldehyde poisoning (2012-2017): 11 cases. J Vet Emerg Crit Care (San Antonio). 2020; https://doi.org/10.1111/vec.12934

Thompson GR, Rosenkrantz H, Schaeppi UH, Braude MC. Comparison of acute oral toxicity of cannabinoids in rats, dogs and monkeys. Toxicol Appl Pharmacol. 1973; 25:(3)363-72

Volmer PA. Human drugs of abuse. In: Bonagura JD, Twedt DC (eds). St Louis (MO): Saunders Elsevier; 2009

Volmer PA, Khan SA, Knight MW, Hansen SR. Warning against use of some permethrin products in cats. J Am Vet Med Assoc. 1998; 213:800-801

Walter SL. Acute penitrem A and roquefortine poisoning in a dog. Can Vet J. 2002; 43:(5)372-374

Weston J. Marijuana poisoning. Control & Therapy Series. 2003; 229

Whittem T. Pyrethrin and pyrethroid insecticide intoxication in cats. Compend Contin Educ Pract Vet. 1995; 17:489-492

Yas-Natan E, Segev G, Aroch I. Clinical, neurological and clinicopathological signs, treatment and outcome of metaldehyde intoxication in 180 dogs. J Sm Anim Pract. 2007; 48:(8)438-443

Young KL, Villar D, Carson TL, Ierman PM, Moore RA, Bottoff MR. Tremorgenic mycotoxin intoxication with penitrem A and roquefortine in two dogs. J Am Vet Med Assoc. 2003; 222:(1)52-3

Poisons affecting the neurological system

02 April 2020
17 mins read
Volume 11 · Issue 3
Box 1.

Abstract

The brain is susceptible to a variety of poisons. Sedating drugs and chemicals can cause central nervous system (CNS) depression while other substances can cause CNS stimulation, including seizures. These are of particular concern since intractable seizure activity may cause complications, with pyrexia resulting in secondary damage to other organs. The common poisons discussed here that cause neurological effects are metaldehyde and tremorgenic mycotoxins, which can cause rapid onset seizures; cannabis, which can cause prolonged sedation in companion animals; permethrin, which is associated with prolonged seizures, particularly in cats; and ivermectin, which can cause CNS depression, blindness and seizures. Treatment is supportive in most cases; care should be taken when considering the use of emetics since there is a risk of aspiration in seizuring animals. Control of seizure activity is a priority, while intravenous lipid emulsion may also be useful.

Many different substances can cause a variety of neurological effects following overdose or accidental exposure. These effects can range from central nervous system (CNS) depression to CNS stimulation and seizures. Complications of prolonged seizure activity include severe pyrexia, which can result in rapid cellular necrosis; rhabdomyolysis, which can lead to acute kidney injury; and disseminated intravascular coagulation (DIC). These complications can lead to multi-organ failure.

Neurological effects from poisons can occur through direct effects on receptors, or as a result of metabolic disturbances. There are species and breed-specific factors that may influence susceptibility to some poisons. Some of the common poisons associated with neurological effects are discussed below; other substances that can cause neurological effects in companion animals are listed in Box 1.

Box 1.Other potential toxicological causes of neurological effects in companion animals

Lipid emulsion may be useful in the management of poisoning with some substances affecting the neurological system, since many are lipophilic. A measure of lipophilicity is the log P; the higher the log P the more lipophilic a compound. If the log P is >1 then lipid emulsion may be useful, although it is not used for substances with a long biological half-life, even if lipophilic.

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