When the phospholipid (PLA2) layer of the cell membrane of tissue is injured or damaged, it leads to the activation and release of inflammatory mediators. These create an acidic environment referred...
There is a growing body of evidence in human medicine regarding pain management in critically ill people, and this supports the notion that effective pain management in humans decreases morbidity and...
There are several prostaglandins involved within the pain process, and these are formed when the COX acts on arachidonic acid. The regulatory and reactionary responses of prostaglandins accounts for...
Eicosanoids are a diverse group of inflammatory mediators including the prostaglandins (PG), thromboxanes (TX) and the leukotrienes. They are derived from the fatty phospholipid bilayer that forms the...