References

The toxicity of iron, an essential element. 2006. http://tinyurl.com/obl6fsx (accessed 2 October 2015)

Companion Animals: Pets at risk from human medicines. Vet Rec. 2014; 175:(15) https://doi.org/10.1136/vr.g6239

Aronson LR, Drobatz K Acetaminophen toxicosis in 17 cats. J Vet Emerg Crit Care. 1996; 6:(2)65-9

Buronfosse F, Buronfosse T, Berny P Breed variability to loperamide susceptibility in dogs. Vet Hum Toxicol. 1998; 40:(3)

Caloni F, Cortinovis C, Pizzo F, Rivolta M, Davanzo F Epidemiological study (2006-2012) on the poisoning of small animals by human and veterinary drugs. Vet Rec. 2014; 174:(9) https://doi.org/10.1136/vr.102107

Cortinovis C, Pizzo F, Caloni F Poisoning of dogs and cats by drugs intended for human use. Vet J. 2015; 203:(1)52-8 https://doi.org/10.1016/j.tvjl.2014.11.004

De Bolle L, Mehuys E, Adriaens E, Remon JP, Van Bortel L, Christiaens T Home medication cabinets and self-medication: a source of potential health threats?. Ann Pharmacother. 2008; 42:(4)572-9 https://doi.org/10.1345/aph.1K533

Dolder LK Methylxanthines, 3rd edn. In: Peterson ME, Talcott PA St Louis: Elsevier Saunders; 2013

Fan TM, Simpson KW, Trasti S, Birnbaum N, Center SA, Yeager A Calcipotriol toxicity in a dog. J Small Anim Pract. 1998; 39:(12)581-6

Hackendahl NC, Sereda CW The dangers of nicotine ingestion in dogs. Vet Med. 2004; 99:(3)218-24

Hilbe M, Sydler T, Fischer L, Naegeli H Metastatic calcification in a dog attributable to ingestion of a tacalcitol ointment. Vet Pathol. 2000; 37:(5)490-2

Hugnet C, Cadore JL, Buronfosse F, Pineau X, Mathet T, Berny PJ Loperamide poisoning in the dog. Vet Hum Toxicol. 1996; 38:(1)31-3

Kan AA, Mulder-Spijkerboer HN, Dijkman MA, de Vries I, Meulenbelt J Common toxic exposure of animals in the Netherlands: a report from the Dutch National Poisons Information Center. Clinical Toxicology. 2015; 53:(4)

Mealey KL Therapeutic implications of the MDR-1 gene. J Vet Pharmacol Ther. 2004; 27:(5)257-64

Mealey KL, Waiting D, Raunig DL, Schmidt KR, Nelson FR Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and ABCB1 wild type dogs. J Vet Pharmacol Ther. 2010; 33:(5)453-60 https://doi.org/10.1111/j.1365-2885.2010.01170.x

Means C Decongestants. In: Plumlee KH St Louis: Mosby; 2004

McLean MK, Hansen SR An overview of trends in animal poisoning cases in the United States: 2002-2010. Vet Clin North Am Small Anim Pract. 2012; 42:(2)219-28 https://doi.org/10.1016/j.cvsm.2011.12.009

Murphy L Antihistamine toxicosis. Vet Med. 2001; 96:(10)752-65

Ooms TG, Khan SA, Means C Suspected caffeine and ephedrine toxicosis resulting from ingestion of an herbal supplement containing guarana and ma huang in dogs: 47 cases (1997-1999). J Am Vet Med Assoc. 2001; 218:(2)225-9

Patterson RJ Lethal caffeine poisoning in a dog. Canine Pract. 1975; 2:(3)51-2

Pesillo SA, Khan SA, Rozanski EA, Rush JE Calcipotriene Toxicosis in a dog successfully treated with Pamidronate Disodium. Journal of Veterinary Emergency and Critical Care. 2002; 12:(3)177-81 https://doi.org/10.1046/j.1435-6935.2002.00022.x

Prasuhn LW Tylenol poisoning in the cat. J Am Vet Med Assoc. 1983; 182:(1)4-5

Sartor LL, Bentjen SA, Trepanier L, Mealey KL Loperamide toxicity in a collie with the MDR1 mutation associated with ivermectin sensitivity. J Vet Intern Med. 2004; 18:(1)117-8

Savides MC, Oehme FW, Nash SL, Leipold HW The toxicity and biotransformation of single doses of acetaminophen in dogs and cats. Toxicol Appl Pharmacol. 1984; 74:(1)26-34

Sellon RK Acetaminophen, 3rd edn. In: Peterson ME, Talcott PA St Louis: Elsevier Saunders; 2013

Spoo W Nicotine Toxicosis. In: Bonagura JD, Twedt DC St Louis: Saunders Elsevier; 2009

Staley EC, Staley EE Loperamide intoxication in a seven-week-old pup. Vet Hum Toxicol. 1994; 36:(5)

Steenberg V Acetaminophen and cats. A dangerous combination. Vet Tech. 2003; 24:(1)43-5

Taylor NS, Dhupa N Acetaminophen toxicity in cats and dogs. Compend Contin Educ Pract Vet. 2000; 22:(2)160-9

Gwaltney-Brant SM, Talcott PA Nonsteroidal antiinflammatories, 3rd edn. In: Peterson ME, Talcott PA St Louis: Elsevier Saunders; 2013

Veterinary Poisons Information Service. Annual Report 2013. 2014. http://tinyurl.com/pwbg3f3 (accessed 2 October 2015)

Veterinary Poisons Information Service. Annual Report 2014. 2015. http://tinyurl.com/qf-zl6d6 (accessed 2 October 2015)

Vig MM, Dalvi RR, Dufuor-Mensah E Acute caffeine poisoning in a dog. Compend Contin Educ Pract Vet. 1986; 8:(2)82-3

Webb CB, Twedt DC, Fettman MJ, Mason G S-adenosylmethionine (SAMe) in a feline acetaminophen model of oxidative injury. J Feline Med Surg. 2003; 5:(2)69-75

World Health Organization. Electronic nicotine delivery systems. 2014. http://tinyurl.com/pd8rjol (accessed 2 October 2015)

Effects of exposure to human medicines in cats and dogs

02 October 2015
10 mins read
Volume 6 · Issue 8

Abstract

Medicines, including both prescription-only and over-the-counter products, are very readily available in the home and are a common source of poisoning in companion animals. Recent studies have shown that analgesics, in particular, are frequently involved in the accidental poisoning of animals, both in Europe and the US. Some medicinal products, such as cold and flu remedies, can contain a variety of ingredients and it is important to obtain details of the exact product involved. This article describes some common medicines found in the home, focusing on over-the-counter products in particular; lists the clinical signs that can occur in the case of an overdose; and describes differences between species where appropriate, as well as briefly outlining treatment.

All households contain some medicines. Most commonly, these probably include analgesics and cold and flu remedies. Numerous prescription-only medications and alternative or herbal remedies are also available. A survey of 288 Belgian homes found an average of 31 (range 6–136) drug packages per household, and a third of these were not stored safely (De Bolle et al, 2008). The most common drugs found were non-opioid analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), nasal decongestants and anti-nausea drugs. Prescription medicine accounted for 34% of the drugs found. As a result of such ready availability of drugs in the home intended for humans, they are common causes of poisoning in companion animals (Cortinovis et al, 2015).

Recently, a report by a pet insurer in the UK found that 78% of veterinary practitioners surveyed had treated pets that had ingested human medication (Anonymous, 2014). Three quarters of these cases involved dogs. NSAIDs, particularly ibuprofen and paracetamol, are the most common drugs involved in enquiries reported to the UK Veterinary Poisons Information Service (VPIS) (2014; 2015) (Figure 1). In Italy, central nervous system (CNS) drugs (commonly sedative-hypnotic drugs and antidepressants) and NSAIDs are the most common human drugs involved in animal poisoning (Caloni et al, 2014). In both the USA (McLean and Hansen, 2012) and the Netherlands (Kan et al, 2015), paracetamol (acetaminophen) and ibuprofen are the most common human drugs ingested by animals.

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