Introducing Microlyte Vet: a new generation of wound technology for optimal wound healing

02 April 2022
3 mins read
Volume 13 · Issue 3
Figure 1. Instead of asking how to ‘treat’ a wound, the group of DVMs, MDs and PhDs at UW-Madison asked, ‘how do we re-engineer the wound bed?’ This change in perspective led to the development of a novel technology: MicroLyte Vet. Jonathan McAnulty, DVM, Chairman of the Department of Surgical Sciences, UW-Madison College of Veterinary Medicine holds a small sample of the product he helped to pioneer.

Abstract

It is not often that you stumble on a new technology that gives you a new perspective on wound care. With over 10 years of research behind it Microlyte offers a new concept as a ‘leave in’ product that combines the antimicrobial power of ionic silver with a hygroscopic film matrix that supports cell migration. This review covers the key points from the workshop, which introduced the science of Microlyte, its features and benefits and its potential applications illustrated across a range of case studies.

MicroLyte Vet contains a microscopic ‘active’ layer and a visible ‘handling’ layer. These layers consist of an advanced polyelectrolyte matrix (PEM) combined with the antimicrobial properties of ionic silver that are laid on an ultra thin hygroscopic polyvinyl film (PVA) membrane.

The dressing (Figure 1) presents as a distinctive transparent orange film that when placed into the wound visibly begins to cling to the wound bed covering the full surface and its contours.

Figure 1. Instead of asking how to ‘treat’ a wound, the group of DVMs, MDs and PhDs at UW-Madison asked, ‘how do we re-engineer the wound bed?’ This change in perspective led to the development of a novel technology: MicroLyte Vet. Jonathan McAnulty, DVM, Chairman of the Department of Surgical Sciences, UW-Madison College of Veterinary Medicine holds a small sample of the product he helped to pioneer.

Wound compatible anti-microbial technology

The structure of Microlyte Vet combines anionic and cationic charged polymeric components that complement the complex chemistry of the wound to support the formation and reorganisation of granulation tissue. Additionally, a low but precise level of bioactive silver is incorporated into the layers to create a very safe but effective antimicrobial environment at the wound bed (Figure 2).

Figure 2. Polyelectrolyte multilayers combined with ionic and metallic silver to offer an antimicrobial effect that is sustained while the dressing is in place.

Why intimacy is important

Many primary dressings with antimicrobial properties are made in textile form perhaps as a woven polymer, synthetic polyurethane or spun fibres. These dressings are often designed for human use for exuding and chronic wounds where capacity to absorb exudate is prioritised; while antimicrobials impregnated into these products act on microbes absorbed into the dressing via wound exudate.

A limitation of dressings of this type is that they may vary in their capacity to conform to the wound bed meaning that pockets of dead space may be left without contact to the dressing and any microbes in those areas may still be able to colonise and develop into more challenging biofilms (Figure 3).

Figure 3. Dead space beneath a dressing can allow colonies of bacteria to survive despite the antimicrobial effects of the dressing. Intimate contact of the wound bed ensures maximum efficacy.

Microlyte's unique film matrix behaves very differently to the more traditional primary dressings. Its hygroscopic nature means that once placed on the wound it literally ‘shrink fits’ to meet the surface of the wound. This intimate contact achieved on a microscopic level ensures that the silver matrix follows the contour of the wound bed rendering pockets of colonising microbes sterile (Figure 3).

When to use Microlyte Vet

Microlyte Vet can be used for a range of presentations where contamination could lead to colonisation, biofilm formation and wound infection.

As presented in the workshop, and outlined by the 3P's of Prepare, Promote, Protect, Georgie Hollis explained that fresh, traumatic, contaminated wounds should be clipped, lavaged, and debrided. Microlyte Vet could be used post debridement to prevent bacterial colonisation and potential biofilm formation. This is particularly important where orthopaedic implants are in place (Figure 4).

Figure 4. Degloving type injury to a 6-year-old Poodle. Case was managed with primary dressing Microlyte Vet, covered by sterile gauze and tape changed at 3–4 day intervals. The wound had completely resolved at 6 weeks with an excellent cosmetic and functional outcome. Case courtesy of: Dr. Louis Gotthelf, Owner, Animal Hospital of Montgomery.

For wounds with established complications as a result of bacterial colonisation or infection, patient care should include proper medical management, where necessary complemented by Microlyte Vet used topically to reduce bacterial proliferation and support granulation tissue formation after the wound is thoroughly cleansed.

Microlyte Vet can been used without a secondary dressing where bandaging and dressing of wounds is causing more trauma than benefit.

When to change the dressing

Mircolyte Vet can stay in place for 4 days and dissolves in situ, therefore avoiding any need to interfere with the wound bed at dressing change. Simply apply another layer and your choice of secondary dressing to avoid interference (Figure 5).

Figure 5. Microlyte dressings adapt to the contours of the wound bed to create an intimate antimicrobial and hydroscopic matrix. The matrix provided supports healing and gradually dissolves over a period of days. The dressings do not need to be removed, just reapplied until healing is achieved. Therefore ensuring minimal disturbance of the delicate wound bed.

Conclusion

Even with best efforts to lavage, debride and adhere to aseptic standards it is likely that some contamination will occur. Where wounds are already challenging because of the extent of tissue loss or implanted devices, the use of Microlyte Vet offers a novel, truly intimate contact layer with the power of ionic silver. It has the potential to be used in a sophisticated way alongside established secondary dressings to further prevent the development of colonies of biofilm forming bacteria, while surrounding and neutralising those that have already begun to take hold.

Figure 6. Case study of a degloving type injury to a 6-year-old Poodle. Case was managed with primary dressing Microlyte Vet, covered by sterile gauze and tape changed at 3–4 day intervals. The wound had completely resolved at 6 weeks with an excellent cosmetic and functional outcome. Case courtesy of: Dr. Louis Gotthelf, Owner, Animal Hospital of Montgomery.