References

Azoulay T Adjunctive cryotherapy for pigmentary keratitis in dogs: a study of 16 corneas. Vet Ophthalmol.. 2014; 17:(4)241-249 https://doi.org/10.1111/vop.12089

Barrett PM, Scagliotti RH, Merideth RE, Jackson PA, Alarcon F Absolute corneal sensitivity and corneal trigeminal nerve anatomy in normal dogs. Prog Vet Comp Ophthalmol.. 1991; 1:(4)245-254

Berdoulay A, English RV, Nadelstein B Effect of topical 0.02% tacrolimus keratoconjunctivitis sicca. Vet Ophthalmol.. 2005; 8:(4)225-232 https://doi.org/10.1111/j.1463-5224.2005.00390.x

Bolzanni H, Oriá AP, Raposo ACS, Sebbag L Aqueous tear assessment in dogs: impact of cephalic conformation, inter-test correlations, and testretest repeatability. Vet Ophthalmol.. 2020; 23:(3)534-543 https://doi.org/10.1111/vop.12751

Carrington S, Bedford P, Guillon J, Woodward E Biomicroscopy of the tear film: the tear film of the pekingese dog. Vet Rec.. 1989; 124:(13)323-328 https://doi.org/10.1136/vr.124.13.323

Conway ED, Stiles J, Townsend WM, Weng HY Evaluation of species differences and the effects of storage duration and temperature on the anticollagenase efficacy of canine, feline, and equine serum on in vitro corneal degradation. Am J Vet Res.. 2015; 76:(11)989-995 https://doi.org/10.2460/ajvr.76.11.989

Costa D, Leiva M, Coyo N, Laguna F, Ríos J, Peña Gimenez MT Effect of topical 1% cyclopentolate hydrochloride on tear production, pupil size, and intraocular pressure in healthy Beagles. Vet Ophthalmol.. 2016; 19:(6)449-453 https://doi.org/10.1111/vop.12323

Costa D, Leiva M, Sanz F A multicenter retrospective study on cryopreserved amniotic membrane transplantation for the treatment of complicated corneal ulcers in the dog. Vet Ophthalmol.. 2019; 22:(5)695-702 https://doi.org/10.1111/vop.12643

Dorbandt DM, Moore PA, Myrna KE Outcome of conjunctival flap repair for corneal defects with and without an acellular submucosa implant in 73 canine eyes. Vet Ophthalmol.. 2015; 18:(2)116-122 https://doi.org/10.1111/vop.12193

Featherstone HJ, Heinrich CL Ophthalmic examination and diagnostics. Part1: The eye examination and diagnostic procedures, 5th ed. In: Gelatt KN, Gilger BC, Kern TJ : Wiley-Blackwell; 2013

Gilger BC, Hamilton HL, Wilkie DA, van der Woerdt A, McLaughlin SA, Whitley RD Traumatic ocular proptoses in dogs and cats: 84 cases (1980-1993). J Am Vet Med Assoc.. 1995; 206:(8)1186-1190

Gilger BC, Bentley E, Ollivier FJ Diseases and surgery of the canine cornea and sclera, 4th ed. In: Gelatt KN Philadelphia: Lea and Febiger; 2007

Giuliano EA Diseases and surgery of the canine lacrimal secretory system, 5th ed. In: Gelatt KN, Gilger BC, Kern TJ : Wiley-Blackwell; 2013

Gogova S, Leiva M, Ortillés Á Corneoconjunctival transposition for the treatment of deep stromal to full-thickness corneal defects in dogs: A multicentric retrospective study of 100 cases (2012-2018). Vet Ophthalmol.. 2020; 23:(3)450-459 https://doi.org/10.1111/vop.12740

Gradilone L, Artiles S, Mendoza E, Morales-Fariña I Clinical evaluation of the effect of diamond burr debridement in pigmentary keratitis in the dog: two case reports: ABSTRACT NO.: 64. Vet Ophthalmol.. 2012; 15:(6) https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1463-5224.2012.01047.x

Guillon JP Non-invasive tearscope plus routine for contact lens fitting. Cont Lens Anterior Eye. 1998; 21:(Suppl 1)S31-S https://doi.org/10.1016/S1367-0484(98)80035-0

Herring IP, Pickett JP, Champagne ES, Marini M Evaluation of aqueous tear production in dogs following general anesthesia. J Am Anim Hosp Assoc.. 2000; 36:(5)427-430 https://doi.org/10.5326/15473317-36-5-427

Herring IP Clinical pharmacology and therapeutics. Part 4: mydriatics/ cycloplegics, anesthetics and tear substitutes and stimulators, 5th ed. In: Gelatt KN, Gilger BC, Kern TJ : Wiley-Blackwell; 2013

Kennel Club. https://www.thekennelclub.org.uk/media/2400/10yrstatsutility.pdf

King-Smith PE, Begley CG, Braun RJ Mechanisms, imaging and structure of tear film breakup. Ocul Surf.. 2018; 16:(1)4-30 https://doi.org/10.1016/j.jtos.2017.09.007

Krecny M, Tichy A, Rushton J, Nell B A retrospective survey of ocular abnormalities in pugs: 130 cases. J Small Anim Pract.. 2015; 56:(2)96-102 https://doi.org/10.1111/jsap.12291

Medial Canthus Syndrome in Dogs—Chronic Tearing, Pigment, Medial Entropion, and Trichiasis. www.hungarovet.com/wp-content/uploads/2009/04/chronic-tearstaining.pdf

Labelle AL, Dresser CB, Hamor RE, Allender MC, Disney JL Characteristics of, prevalence of, and risk factors for corneal pigmentation (pigmentary keratopathy) in Pugs. J Am Vet Med Assoc.. 2013; 243:(5)667-674 https://doi.org/10.2460/javma.243.5.667

Lacerda RP, Peña Gimenez MT, Laguna F, Costa D, Ríos J, Leiva M Corneal grafting for the treatment of full-thickness corneal defects in dogs: a review of 50 cases. Vet Ophthalmol.. 2017; 20:(3)222-231 https://doi.org/10.1111/vop.12392

Maini S, Everson R, Dawson C, Chang YM, Hartley C, Sanchez RF Pigmentary keratitis in pugs in the United Kingdom: prevalence and associated features. BMC Vet Res.. 2019; 15:(1) https://doi.org/10.1186/s12917-019-2127-y

McDonald CC, Kaye SB, Figueiredo FC, Macintosh G, Lockett C A randomised, crossover, multicentre study to compare the performance of 0.1% (w/v) sodium hyaluronate with 1.4% (w/v) polyvinyl alcohol in the alleviation of symptoms associated with dry eye syndrome. Eye (Lond). 2002; 16:(5)601-607 https://doi.org/10.1038/sj.eye.6700169

Moore CP Qualitative tear film disease. Vet Clin North Am Small Anim Pract.. 1990; 20:(3)565-581 https://doi.org/10.1016/S0195-5616(90)50071-6

Moore CP, McHugh JB, Thorne JG, Phillips TE Effect of cyclosporine on conjunctival mucin in a canine keratoconjunctivitis sicca model. Invest Ophthalmol Vis Sci.. 2001; 42:(3)653-659

Morgan RV, Abrams KL Topical administration of cyclosporine for treatment of keratoconjunctivitis sicca in dogs. J Am Vet Med Assoc.. 1991; 199:(8)1043-1046

Ollivier FJ, Gilger BC, Barrie KP, Kallberg ME, Plummer CE, O'Reilly S, Gelatt KN, Brooks DE Proteinases of the cornea and preocular tear film. Vet Ophthalmol.. 2007; 10:(4)199-206 https://doi.org/10.1111/j.1463-5224.2007.00546.x

O'Neill DG, Darwent EC, Church DB, Brodbelt DC Demography and health of Pugs under primary veterinary care in England. Canine Genet Epidemiol.. 2016; 3:(1) https://doi.org/10.1186/s40575-016-0035-z

Packer RMA, Hendricks A, Burn CC Impact of facial conformation on canine health: corneal ulceration. PLoS One.. 2015a; 10:(5) https://doi.org/10.1371/journal.pone.0123827

Packer RMA, Hendricks A, Tivers MS, Burn CC Impact of Facial Conformation on Canine Health: Brachycephalic Obstructive Airway Syndrome. PLoS One.. 2015b; 10:(10) https://doi.org/10.1371/journal.pone.0137496

Packer RMA, Murphy D, Farnworth MJ Purchasing popular purebreds: investigating the influence of breed-type on the pre-purchase motivations and behaviour of dog owners. Anim Welf.. 2017; 26:(2)191-201 https://doi.org/10.7120/09627286.26.2.191

Palella Gómez A, Mazzucchelli S, Scurrell E, Smith K, Pinheiro de Lacerda R Evaluation of partial tarsal plate excision using a transconjunctival approach for the treatment of distichiasis in dogs. Vet Ophthalmol.. 2020; 23:(3)506-514 https://doi.org/10.1111/vop.12748

Roberts SM, Severin GA, Lavach JD Antibacterial activity of dilute povidone-iodine solutions used for ocular surface disinfection in dogs. Am J Vet Res.. 1986; 47:(6)1207-1210

Romkes G, Klopfleisch R, Eule JC Evaluation of one-vs. two-layered closure after wedge excision of 43 eyelid tumors in dogs. Vet Ophthalmol.. 2014; 17:(1)32-40 https://doi.org/10.1111/vop.12033

Salisbury MA, Kaswan RL, Ward DA, Martin CL, Ramsey JM, Fischer CA Topical application of cyclosporine in the management of keratoconjunctivitis sicca in dogs. J Am Anim Hosp Assoc.. 1990; 26:(3)269-274

Stades FC, Van Der Woerdt A Diseases and surgery of the canine eyelid, 5th ed. In: Gelatt KN, Gilger BC, Kern TJ : Wiley-Blackwell; 2013

Sternglanz SH, Gray JL, Murakami M Adult preferences for infantile facial features: an ethological approach. Anim Behav.. 1977; 25:(1)108-115 https://doi.org/10.1016/0003-3472(77)90072-0

Strauss RA, Genschel U, Allbaugh RA, Sebbag L, Ben-Shlomo G Evaluation of microbial contamination of canine plasma eyedropper bottles following clinical use in canine patients. Vet Ophthalmol.. 2019; 22:(3)222-228 https://doi.org/10.1111/vop.12580

Willcox MDP, Argüeso P, Georgiev GA TFOS DEWS II Tear Film Report. Ocul Surf. 2017; 15:(3)366-403 https://doi.org/10.1016/j.jtos.2017.03.006

Williams DL, Mann BK Efficacy of a crosslinked hyaluronic acid-based hydrogel as a tear film supplement: a masked controlled study. PLoS One.. 2014; 9:(6) https://doi.org/10.1371/journal.pone.0099766

Williams DL, Wirostko BM, Gum G, Mann BK Topical Cross-Linked HABased Hydrogel Accelerates Closure of Corneal Epithelial Defects and Repair of Stromal Ulceration in Companion Animals. Invest Ophthalmol Vis Sci.. 2017; 58:(11)4616-4622 https://doi.org/10.1167/iovs.16-20848

Wirostko B, Mann BK, Williams DL, Prestwich GD Ophthalmic Uses of a Thiol-Modified Hyaluronan-Based Hydrogel. Adv Wound Care. 2014; 3:(11)708-716 https://doi.org/10.1089/wound.2014.0572

Wolffsohn JS, Arita R, Chalmers R, Djalilian A, Dogru M, Dumbleton K, Gupta PK, Karpecki P, Lazreg S, Pult H TFOS DEWS II Diagnostic Methodology report. Ocul Surf.. 2017; 15:(3)539-574 https://doi.org/10.1016/j.jtos.2017.05.001

Yi NY, Park SA, Jeong MB Medial canthoplasty for epiphora in dogs: a retrospective study of 23 cases. J Am Anim Hosp Assoc.. 2006; 42:(6)435-439 https://doi.org/10.5326/0420435

Brachycephalic ocular syndrome

02 October 2020

Clinical

13 mins read

02 October 2020

Volume 11 · Issue 8

ISSN (print): 2044-0065

ISSN (online): 2052-2959

Figure 1 A macropalpebral fissue with a large area of medial scleral exposure and medial trichiasis as a result of entropion.

Abstract

The small brachycephalic breeds such as the Pug and French Bulldog are currently extremely popular. The conformation of these breeds is part of their appeal to owners, however it leads to ocular surface disease such as corneal ulceration and pigmentation. The eye problems associated with these breeds are collectively known as brachycephalic ocular syndrome. In the normal situation there is a close interaction between the tear film, the eyelids and the cornea, which in the affected breeds is disrupted. Treatment needs to address the causes of the problem, such as lid anatomy, as well as the resultant corneal disease. Combinations of both medical and surgical treatment are required. Hospitalisation and anaesthesia of these cases requires careful, gentle handling and caution to prevent respiratory distress and damage to their often fragile eyes.

Small brachycephalic breeds are especially popular currently. Based on Kennel Club figures, in the 10 years between 2010 and 2019 there was a significant increase in Kennel Club registrations, with a 1527% increase in French Bulldog registrations (Kennel Club, 2020).

The neonatal appearance of the breeds (enlarged forehead, eyes, and head size relative to the trunk) may be at least part of the reason these dogs are found attractive (Sternglanz et al, 1977; Packer et al, 2017). Facial morphology may increase the frequency of eye disorders (Packer et al, 2015a), and ophthalmological disease is the most prevalent group-level disease in Pugs (16.25% prevalence) with corneal disorder being the second most prevalent diagnosis-level disorder (8.72%) after obesity (O‘Neill et al, 2016).

The term brachycephalic ocular syndrome (BOS) is used to describe the eye problems, associated with conformation (exophthalmia, shallow orbit, lagophthalmia, euryblepharon, trichiasis, medial lower lid entropion, exoptropia and involution of the medial canthus) in small brachycephalic breeds such as the Pug or French bulldog. These dogs often present with poor corneal health and poor-quality tear films (Carrington et al. 1989; Krohne, 2008; Stades and Van Der Woerdt, 2013) (Figure 1).

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