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Canine angiostrongylosis: an update

22 September 2014
9 mins read
Volume 5 · Issue 7

Abstract

The canine ‘lungworm’, Angiostrongylus vasorum, continues to grab the headlines when it comes to parasite infections of dogs in the UK. Geographical spread appears to continue apace, with fresh evidence of autocthonous infections in northern England and Scotland, leading practices to constantly re-evaluate their advice to clients on preventive worming regimens, as well as their approach to respiratory and other presentations in dogs. Recent developments offer improved information in support of practice decisions in these areas. In particular, a new point-of-care test based on detection of circulating worm antigen should help to support definitive diagnosis, so often elusive using previous tests, and to revolutionise awareness of the local level of risk. This and related serological tests are underpinning large-scale surveys to provide new epidemiological insights. The options for treatment and control of infection are also expanding, with milbemycin oxime joining moxidectin in having been shown to prevent patent infection. Surveys of clinical incidence suggest that increased awareness and improved control of the parasite can quell disease in identified ‘hotspots’. Therefore, although the threat of angiostrongylosis seems to be increasing in the UK, and extending to new areas, a growing toolkit for diagnosis and control places the veterinary professions in a strong position to counter this threat. Veterinary nurses have a particularly important role in providing laboratory support for evidence-based medicine, and for leading informed discussion of risks with dog owners. This should enable appropriate, risk-based advice on preventive worming regimens for dogs. Ongoing research suggests that other factors, such as age, breed, and individual behaviour, might also be taken into account to ensure that dogs are appropriately protected from this often mild, but potentially fatal, parasitic infection.

Care must be taken when describing Angiostrongylus vasorum infections as ‘lungworm’, since other nematode species, especially Crenosoma vulpis, are also causes of respiratory disease in dogs in the UK (McGarry and Morgan, 2009). The life cycle of A. vasorum is well established (Bolt et al, 1994). Important points to note are that first stage larvae (L1) (Figure 1) pass out in the faeces, and develop further in gastropod mollusc (slug and snail) intermediate hosts, with infection occurring when dogs ingest infective third stage larvae (L3). This is most likely to occur through intentional or accidental consumption of infected slugs or snails (Morgan et al, 2005). Infection in dogs most often causes mild to moderate respiratory disease, though a wide range of presenting signs is possible and disease can be severe and sometimes fatal (Koch and Willesen, 2009). These other signs are largely caused by bleeding disorders, the mechanism of which is unclear, and can result in neurological, gastrointestinal, ocular, dermatological or other disease depending on the site of the bleeding. Persistent bleeding after injury or surgery can occur. Other signs such as syncope, lethargy, and stunted growth are probably attributable to lung pathology. Treatment of angiostrongylosis focuses on killing the worms, and this can be achieved by administration of one of a range of anthelmintic drugs, as discussed below. Supportive treatment is recommended depending on the clinical signs (Koch and Willesen 2009; Helm et al, 2010).

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